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Using Genomic Analysis to Improve Mammalian Cell Culture for Biopharmaceutical Production

By: Susan Dana Jones and Dawn M. Ecker
Reprinted with the permission of Pharmaceutical Processing, October 2013

Monoclonal antibodies, currently the dominant class of biopharmaceuticals, generally require mammalian cell culture production to enable addition of critical post-translational modifications such as glycosylation. Since these products are often given to patients at high doses, total bulk drug requirements for a single product can be as high as 7,000 kg per year. To be able to meet this high demand, the industry has developed cell line development and cell culture technologies that improve the overall performance and viability of production cell lines in the bioreactor. This article reviews emerging approaches to improving biopharmaceutical production cell lines and cell culture performance through the application of genomics and related technologies.