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The Use of Disposable Technology for Downstream Processing

Presented at: Cambridge Healthtech Institute Immunotherapeutics & Vaccine Summit; Short Course: Single Use Systems (Disposables) for Vaccine Manufacture Cambridge, MA, August 16-19, 2010

With the rapid advance of single-use and disposable-format bioreactors and other technologies enabling rapid and efficient production of vaccines, the demand for disposable-format downstream process technologies is increasing. While single-use capsule filters have been used in biomanufacturing for decades, other downstream unit operations, such as chromatography and tangential flow filtration, have been slower to evolve scalable disposable-format technologies. This presentation will provide a review of the driving forces for adoption of single-use technologies as well as an overview of recent advances in disposable-format technologies for downstream processing.