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Performance by Design: Engineering Functionality into Biopharmaceutical Products

Presented at: Cambridge Healthtech Institute Peptalk San Diego, CA, Jan 10-14, 2011

Most cell line development technologies focus on obtaining high titers quickly with little to no attention paid to post-translational modifications and potential product heterogeneity. A more effective approach would be to use cells engineered to produce the desired post-translational modifications as well as achieve high titers. This “Performance by Design” truly reflect the goals of Quality by Design by enabling a rational approach to the production of product with desired quality attributes.