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Neither beast nor bird: addressing biomanufacturing challenges with new expression systems

Presented at: BIO International Convention; 2012 Jun 18-21; Boston, MA.

Of the many different types of biomolecule expression systems that have been tried, mammalian, primarily CHO cell, and E coli systems have remained the mainstays of biologic manufacturing, accounting for nearly 90 percent of the systems that produce today’s marketed biopharmaceuticals.  The emergence of biosimilars, other pressures to reduce costs, an increase in the number of challenges to manufacturing proteins, and the inventiveness of bioengineers, are creating new opportunities for alternatives. These slides were presented as part of Mr. Ransohoff’s introductory remarks for this panel which examined several of these systems and their potential in the current environment as well as barriers to adoption.