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Disposable Technologies for Purification of Biopharmaceuticals

Presented at: the NE Local Section SIM Meeting Boston, MA, December 14, 2009

With the rapid advance of single-use and disposable-format bioreactors and other technologies enabling large-scale production of biopharmaceuticals using disposable technologies, the demand for disposable-format downstream process technologies is increasing. While single-use capsule filters have been used in biomaufacturing for decades, other downstream unit operations, such as chromatography and tangential flow filtration have been slower to evolve scalable disposable-format technologies. This presentation provides a review of the driving forces for adoption of single-use technologies as well as an overview of recent advances in disposable-format technologies specifically applicable to the purification and downstream processing sections of the biopharmaceutical flowpath.