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Advances in Disposable-Format Downstream Processing Technologies

Presented at: BioProcess International Conference Anaheim, CA, September 23, 2008

With the rapid advance of single-use and disposable-format bioreactors and other technologies enabling large-scale disposable bioprocessing, the demand for disposable-format downstream process technologies is increasing. While disposable capsule filters have been used in biomaufacturing for decades, other downstream unit operations, such as chromatography and tangential flow filtration have been slower to evolve scalable disposable-format technologies. This presentation will provide an overview of the driving forces for adoption of single-use and disposable-format technologies as well as an overview of recent advances specifically applicable to the purification and downstream processing sections of the biopharmaceutical flowpath.