Get Social With Us

Single Use Products for Bioproduction: Available Options for Upstream and Downstream Processing

By: Susan Dana Jones and Thomas C. Ransohoff
Reprinted with permission of American Pharmaceutical Review, May/June 2011

Single use bioreactors for cell culture, single pass TFF systems for harvest, and disposable options for downstream processing have begun to see greater use in bioproduction. The significant advantages of single use technology in multi-product facilities such as contract manufacturing organizations and in enabling in-house production of early stage clinical material have enabled these technologies to gain a foothold in the bioproduction industry. In this article, the technology breakthroughs, regulatory concerns and solutions, and available types of single use bioreactors and downstream processing equipment will be reviewed.