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Mycoplasma — Recent Developments in Detecting and in Preventing Bioreactor Contamination

Presented at: ISPE Annual Meeting Scottsdale, Arizona, November 6-10, 2005

In this presentation, the implications of mycoplasma contamination on cell culture companies are discussed along with two primary means used to reduce risk of contamination in large scale operations — heat treatment and media filtration. The biology and detection methods, including recent developments, are discussed, along with common contamination sources and the principles of filtration governing mycoplasma removal. Experimental data on mycoplasma filtration efficiency for different filter makes during filter challenge studies is presented.