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Economics of modular facility design and construction

Presented at:

Cambridge Healthtech Institute’s 13th Annual PepTalk; 2014 Jan 13-17; Palm Springs, CA.

The convergent of trends in new product development towards more personalized or niche products and more efficacious products such as antibody drug conjugates with improved cell line productivity and process intensification and advances in single use technologies have led to a paradigm shift in the industry’s approach to facility design and construction. Today’s biopharmaceutical production facilities must be flexible, cost effective, and readily constructed with minimal capital investment and construction timelines. The results of a process economic study comparing the capital and operating costs of a monoclonal antibody production facility using either traditional reusable stainless steel equipment or single use technologies will be presented along with a standardized facility design incorporating single use technologies and modular construction.