The State of Mammalian Cell Culture Biomanufacturing

This report offers an in-depth review of the growth in sales and production demand for biopharmaceutical products currently on the market and in development. The report provides a comprehensive analysis of the current and future supply and demand for mammalian cell culture capacity, including the geographic distribution of manufacturing capacity, the impact of facility utilization rates on overall capacity requirements, and the influence of emerging technologies on manufacturing facility design and utilization.

Drawing from BPTC^®’s proprietary Biopharmaceutical Product database, this report highlights the continued growth of total biopharmaceutical sales in 2010 to $107 billion, or approximately 12% of the total pharmaceutical market. We review the production methods used for the top biopharmaceutical “blockbuster” products and analyze the impact of those produced in mammalian cell culture on global manufacturing capacity showing that despite the continued growth in sales of these products and the associated requirement for increasing mammalian cell culture capacity to meet this market demand, overall capacity utilization rates have remained low due to technological advances. Our analysis shows that industry-wide capacity utilization will increase approximately 50% from 2011 to 2016 as construction of new capacity slows and more products reach the market.

The impact of this increasing utilization rate on biomanufacturing capacity and the current concentration of this capacity in a small number of companies may limit some company’s ability to access capacity in a timely manner. While the five product companies controlling the majority of cell culture manufacturing capacity have more than enough capacity to accommodate their anticipated future needs and keep their own utilization rates low, many of the remaining companies, which either have smaller-scale manufacturing capacity or are relying on CMOs, may find a need for additional capacity by 2016 suggesting that CMOs and smaller biopharmaceutical companies may announce the installation of new capacity in the coming years.

This 150-page report provides an unrivaled analysis of the drivers of biomanufacturing supply and demand. With 38 figures and graphs and 27 tables, including a comprehensive list of sales data and bulk product requirements for all biopharmaceutical products produced in mammalian cell culture currently on the market, The State of Mammalian Cell Culture Biomanufacturing provides detailed, data-driven insight into the biomanufacturing market to inform senior executives and program managers with the essential and timely information needed to fully understand the mammalian cell culture biomanufacturing landscape and to stay competitive.

View the Table of Contents here.

Available only by download, in PDF format.